4-Methoxybenzenesulfonyl chloride → N-(3-Acetyl-2-hydroxyphenyl)-4-methoxybenzenesulfonamide
反応式
Br.[NH2:2][C:3]1[C:4]([OH:12])=[C:5]([C:9](=[O:11])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1>N1C=CC=CC=1>[C:9]([C:5]1[C:4]([OH:12])=[C:3]([NH:2][S:21]([C:18]2[CH:17]=[CH:16][C:15]([O:14][CH3:13])=[CH:20][CH:19]=2)(=[O:23])=[O:22])[CH:8]=[CH:7][CH:6]=1)(=[O:11])[CH3:10]参加物
4
実験手順
A solution of 3'-amino-2'-hydroxyacetophenone hydrobromide (1.282 g, 5.52 mmol) in pyridine (25 ml) was added at 0° C. with 4-methoxybenzenesulfonyl chloride (1.18 g, 5.71 mmol) dissolved in the minimum amount of pyridine and the mixture was left at room temperature for 18 h. Afterwards it was evaporated to dryness, redissolved in dichloromethane, washed with 1M HCl, dried and the solvent was evaporated off under reduced pressure, thereby obtaining 1.479 g of the title compound (81% yield).