Acetic Acid → 4-(Pyridin-3-yl)-1,2-oxazol-5-amine

HRID 1604398ノート

反応式

HRID 1604398 の反応式
CN(C)[CH:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4]#[N:5].Cl.[NH2:14]O.[C:16]([OH:19])(=O)C>>[NH2:14][C:16]1[O:19][N:5]=[CH:4][C:3]=1[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 443297Hydroxyamine hydrochlorideHCID 19603622HCID 19603622、化合物

生成物 1

HCID 167406694-(Pyridin-3-yl)-1,2-oxazol-5-amine

反応条件

温度
100 °C

実験手順

To a solution of α-(dimethylamino)-α-(3-pyridyl)acetonitrile (5.19 g, 30 mmol) in acetic acid (40 ml) was added hydroxylamine hydrochloride (2.8 g, 40 mmol). The reaction mixture was stirred at 100° C. for 1 hour, cooled to room temperature and concentrated in vacuo. Water (50 ml) was added and the reaction mixture neutralized with solid potassium carbonate. The precipitated compound was filtered washed with water and dried giving the title compound in 4.2 g yield.

後処理

  1. temperaturecooled to room temperature
  2. concentrationconcentrated in vacuo
  3. additionWater (50 ml) was added
  4. filtrationThe precipitated compound was filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-44726756555341708a135445766640bd
出典データセット
uspto-grants-1999_11
特許番号
US05994373

反応ノート

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