Hydrazine hydrate (1:1) → 3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline

HRID 1604524

反応式

HRID 1604524 の反応式
[Si:1]([O:18][CH2:19][C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[C:22]([N+:27]([O-])=O)[C:21]=1[Cl:30])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN>CO.O>[NH2:27][C:22]1[C:21]([Cl:30])=[C:20]([CH2:19][O:18][Si:1]([C:14]([CH3:16])([CH3:15])[CH3:17])([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:25]([Cl:26])=[CH:24][CH:23]=1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 117981851-(Tert-butyldiphenylsilyloxymethyl)-2,6-dichloro-3-nitrobenzene

生成物 1

HCID 105987193-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline収率 86%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a stirred mixture of 1-(tert-butyldiphenylsilyloxy-methyl)-2,6-dichloro-3-nitrobenzene (433 mg), ferric chloride hexahydrate (17.5 mg) and activated carbon (17.5 mg) in a mixture of methanol (2.78 ml) and water (0.69 ml) was added hydrazine monohydrate (0.135 ml) dropwise at 60-70° C. After the addition was finished, the mixture was refluxed for half an hour. The mixture was allowed to cool and filtered. The filtrate was concentrated in vacuo. The residue was extracted with dichloromethane and the organic phase was dried over anhydrous magnesium sulfate. After being filtered, the filtrate was concentrated in vacuo and the resulting residue was washed with n-hexane to give 3-amino-1-(tert-butyldiphenylsilyoxymethyl)-2,6-dichlorobenzene (348 mg) as a white mass.

後処理

  1. additionAfter the addition
  2. temperaturethe mixture was refluxed for half an hour
  3. temperatureto cool
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated in vacuo
  6. extractionThe residue was extracted with dichloromethane
  7. dry with materialthe organic phase was dried over anhydrous magnesium sulfate
  8. filtrationAfter being filtered
  9. concentrationthe filtrate was concentrated in vacuo
  10. washthe resulting residue was washed with n-hexane

出典と根拠

ORDレコード
ord-6fe7d8b972dd450298cc3321141ce750
出典データセット
uspto-grants-1999_11
特許番号
US05994368

関連ノート

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