Hydrochloric Acid → 2-Methyl-4-phenylquinolin-8-ol

HRID 1604585ノート

反応式

HRID 1604585 の反応式
[OH:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=O)/[CH:10]=[CH:11]/[CH3:12].Cl.O.N>>[OH:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[C:11]([CH3:12])[CH:10]=[C:9]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 58012-AminophenolHCID 231934Phenyl propenyl ketoneHCID 12896473Azane;hydrate

生成物 1

HCID 196034182-Methyl-4-phenylquinolin-8-ol収率 55.7%

実験手順

A mixture of 2-hydroxyaniline (2 g), crotonoylbenzene (8.03 g) and concentrated hydrochloric acid (8 ml) was refluxed for 24 hours. The mixture was neutralized with concentrated ammonia water under ice-cooling, and extracted with chloroform. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified according to a conventional manner to give 8-hydroxy-2-methyl-4-phenylquinoline (2.4 g) as an oil.

後処理

  1. temperaturewas refluxed for 24 hours
  2. temperaturecooling
  3. extractionextracted with chloroform
  4. washThe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified

出典と根拠

ORDレコード
ord-94f642f325e0476c8ea84bc8f709a403
出典データセット
uspto-grants-1999_11
特許番号
US05994368

反応ノート

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