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Water → 3-[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yl]propanol

HRID 1604636
ノート
印刷プレビュー

反応式

HRID 1604636 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([C:11]1[N:12]=[C:13]([C:16]2[O:17][C:18]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27](OCC)=[O:28])=[CH:21][C:19]=3[CH:20]=2)[S:14][CH:15]=1)([CH3:10])([CH3:9])[CH3:8].O>O1CCCC1>[C:7]([C:11]1[N:12]=[C:13]([C:16]2[O:17][C:18]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH2:27][OH:28])=[CH:21][C:19]=3[CH:20]=2)[S:14][CH:15]=1)([CH3:10])([CH3:8])[CH3:9]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 962WaterHCID 19603662Ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 196037673-[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yl]propanol収率 73.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Lithium aluminium hydride (0.14 g) was added to a solution of ethyl 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propionate (0.65 g) in tetrahydrofuran (10 ml) at room temperature under an inert atmosphere. After the mixture was stirred for 2 hours, water was added to the mixture. The resulting precipitates were filtered off and the filtrate was extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to give 3-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]propanol (0.42 g).

後処理

  1. customThe resulting precipitates
  2. filtrationwere filtered off
  3. extractionthe filtrate was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f0d9653e011b491d9e2f28933dd81c28
出典データセット
uspto-grants-1999_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05994378

反応ノート

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