1,2-Epoxybutane → 3-Phenyl-2(S)-phthalimidopropan-1-al

HRID 1604747ノート

反応式

HRID 1604747 の反応式
[C:1]1([CH2:7][C@H:8]([N:12]2[C:16](=[O:17])[C:15]3=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]3[C:13]2=[O:22])[C:9](Cl)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1OC1CC>C1(C)C=CC=CC=1.[Pd]>[C:1]1([CH2:7][C@H:8]([N:12]2[C:16](=[O:17])[C:15]3=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]3[C:13]2=[O:22])[CH:9]=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 78341,2-EpoxybutaneHCID 105671973-phenyl-2(S)-phthalimidopropionyl chloride

生成物 1

HCID 110658013-Phenyl-2(S)-phthalimidopropan-1-al

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 1140Toluene溶媒2 回

実験手順

The solution containing the 3-phenyl-2(S)-phthal-imidopropionyl chloride was diluted with 500 ml of toluene and combined with 72.11 g of 1,2-butylene oxide. 23.5 g of palladium on carbon (5%) and 100 ml of toluene were added to the solution. The suspension was hydrogenated for 17 hours with stirring and then filtered and the residue washed with 200 ml of toluene, wherein 3-phenyl-2(S)-phthalimidopropan-1-al was obtained.

後処理

  1. filtrationfiltered
  2. washthe residue washed with 200 ml of toluene

出典と根拠

ORDレコード
ord-48d3e33722a84601ad0fa0268b32d2cf
出典データセット
uspto-grants-1999_11
特許番号
US05994555

反応ノート

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