Benzene → Isopropyl 11-methylthio-3,7,11-trimethyldodeca-2,4-dienoate

HRID 1605135ノート

反応式

HRID 1605135 の反応式
[CH3:1][S:2][C:3]([CH3:19])([CH3:18])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:17])[CH2:8][CH:9]=[CH:10][C:11]([CH3:16])=[CH:12][C:13]([OH:15])=[O:14].[CH:20]1[CH:25]=CC=C[CH:21]=1.C(Cl)(=O)C(Cl)=O.C(=O)(O)[O-].[Na+]>CCOCC.C(O)(C)C>[CH3:1][S:2][C:3]([CH3:18])([CH3:19])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:17])[CH2:8][CH:9]=[CH:10][C:11]([CH3:16])=[CH:12][C:13]([O:15][CH:20]([CH3:25])[CH3:21])=[O:14]

参加物

7

反応物 4

HCID 241BenzeneHCID 65578Oxalyl chlorideHCID 516892Sodium BicarbonateHCID 5422430711-Methylthio-3,7,11-trimethyldodeca-2,4-dienoic acid

生成物 1

HCID 54300429Isopropyl 11-methylthio-3,7,11-trimethyldodeca-2,4-dienoate

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 3776Isopropanol溶媒

実験手順

To 0.6 g. of 11-methylthio-3,7,11-trimethyldodeca-2,4-dienoic acid in 10 ml. of dry benzene is added 0.23 ml. of oxalyl chloride at room temperature with stirring. After 2 hours, isopropanol (2ml.) is added and the mixture allowed to stand at room temperature for about 2 hours. Ether and saturated sodium bicarbonate is added and the organic phase separated. The organic phase is washed with aqueous sodium bicarbonate, saturated sodium chloride, dried over calcium sulfate and evaporated to yield isopropyl 11-methylthio-3,7,11-trimethyldodeca-2,4-dienoate.

後処理

  1. waitto stand at room temperature for about 2 hours
  2. customthe organic phase separated
  3. washThe organic phase is washed with aqueous sodium bicarbonate, saturated sodium chloride
  4. dry with materialdried over calcium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-2275bdf051b343de9dcf80ef654d801d
出典データセット
uspto-grants-1976_04
特許番号
US03948996

反応ノート

読み込み中…