Methane → HCID 12650295、化合物

HRID 1605168ノート

反応式

HRID 1605168 の反応式
Cl[C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].C>O.[Cu].CN(C)C=O>[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:2]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:15][CH:14]=1

参加物

8

反応物 4

HCID 297MethaneHCID 2879P-CresolHCID 57872,4-Dichlorobenzoic AcidHCID 11430Potassium Carbonate

生成物 1

HCID 12650295HCID 12650295、化合物

試薬・触媒・溶媒 3

HCID 23978Copper触媒HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 15 g. of 2,4-dichlorobenzoic acid, 10 g. of p-methylphenol, 0.5 g. of copper powder and 20 g. of anhydrous potassium carbonate in 200 ml. of dimethylformamide is heated to 165° C and maintained thereat with stirring and under a nitrogen atmosphere. After monitoring via tlc indicates the reaction is substantially complete, the reaction mixture is diluted with water, treated with charcoal, filtered and the clear filtrate acidified. The precipitate is isolated by suction filtration, washed neutral and dried to give 2-(p-methylphenyloxy)-4-chlorobenzoic acid.

後処理

  1. additionA mixture of 15 g
  2. temperaturemaintained
  3. filtrationfiltered
  4. customThe precipitate is isolated by suction filtration
  5. washwashed neutral
  6. customdried

出典と根拠

ORDレコード
ord-ea08849779bf48ec85d709fd9f0fa43b
出典データセット
uspto-grants-1976_04
特許番号
US03949084

反応ノート

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