Ethanol → 2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
反応式
C(=O)(O)[O-].[Na+].[CH3:6][C:7]1[NH:12][C:11](=[S:13])[NH:10][C:9](=[O:14])[CH:8]=1.Cl[CH2:16][C:17]([NH2:19])=[O:18].C(O)C>O>[OH:14][C:9]1[CH:8]=[C:7]([CH3:6])[N:12]=[C:11]([S:13][CH2:16][C:17]([NH2:19])=[O:18])[N:10]=1参加物
6
実験手順
To a solution of 16.8 g. (0.2 mole) of sodium bicarbonate in 300 ml of water was added 22.8 g.(0.2 mole) of 6-methyl-2-thiouracil. The mixture was heated on a steam bath for 10 minutes. To this mixture was then added 18.6 g.(0.2 mole) of 2-chloroacetamide followed by 100 ml of absolute ethanol. The mixture was heated on a steam bath for 2 hours. The solution was cooled in an ice bath and the precipitate which formed was collected and recrystallized from a mixture of N,N-dimethylformamide and ethanol to afford 8 g. of product, m.p. 238°-240° d.
後処理
- temperatureThe mixture was heated on a steam bath for 10 minutes
- additionTo this mixture was then added 18.6 g
- temperatureThe mixture was heated on a steam bath for 2 hours
- temperatureThe solution was cooled in an ice bath
- customthe precipitate which formed
- customwas collected
- customrecrystallized from a mixture of N,N-dimethylformamide and ethanol
- customto afford 8 g
出典と根拠
- ORDレコード
- ord-eb47cb79e7614aabb6349f98472e05d1
- 出典データセット
- uspto-grants-1976_04
- 特許番号
- US03950339
反応ノート
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