Sodium Carbonate → 5-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid

HRID 1605253ノート

反応式

HRID 1605253 の反応式
[O:1]=[C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH2:12][CH3:13])[CH:4]=[C:3]1[C:14]([O:16]CC)=[O:15].C([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C>[O:1]=[C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH2:12][CH3:13])[CH:4]=[C:3]1[C:14]([OH:16])=[O:15]

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 227568395-Oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

生成物 1

HCID 227568245-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

0.6 g. of this ester and 10 cm3 of a 10% solution of Na2CO3 are heated under reflux for 20 minutes. After cooling, the solution is acidified by means of acetic acid. The precipitate (0.5 g.) is filtered off and recrystallised from water. 0.2 g. of 5-oxo-8-ethyl-5,8-dihydro-pyrido-(2,3-d)pyrimidine-6-carboxylic acid is obtained, melting point 225°C. (decomposition).

後処理

  1. temperatureunder reflux for 20 minutes
  2. temperatureAfter cooling
  3. filtrationThe precipitate (0.5 g.) is filtered off
  4. customrecrystallised from water

出典と根拠

ORDレコード
ord-2a4de49a5c5f4cd6b9b2989886c6ba4c
出典データセット
uspto-grants-1976_04
特許番号
US03950338

反応ノート

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