Hydroxyamine hydrochloride → 3-Formylindole-4-carboxylic acid methyl ester oxime

HRID 1605262ノート

反応式

HRID 1605262 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:6]2[C:7]([CH:14]=[O:15])=[CH:8][NH:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)=O.Cl.[NH2:17][OH:18].C([O-])(=O)C.[Na+]>CO>[CH3:1][O:2][C:3](=[N:17][OH:18])[C:5]1[C:6]2[C:7]([CH:14]=[O:15])=[CH:8][NH:9][C:10]=2[CH:11]=[CH:12][CH:13]=1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 12396096methyl 3-formyl-1H-indole-4-carboxylate

生成物 1

HCID 867332223-Formylindole-4-carboxylic acid methyl ester oxime

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3-formyl -4-indolecarboxylic acid methyl ester (2.03 g), described in Example 1, 10 ml of a 5M aqueous solution of hydroxylamine hydrochloride, 10 of 5M aqueous sodium acetate and 20 ml. of methanol is stirred at 45°-55°C for 1 hr. The precipitate is collected and washed with cold water. Recrystallization from methanol-water gives the title compound, mp 178°-179°C.

後処理

  1. customThe precipitate is collected
  2. washwashed with cold water
  3. customRecrystallization from methanol-water

出典と根拠

ORDレコード
ord-dc278f365f404a08bfdb845ea412e462
出典データセット
uspto-grants-1976_04
特許番号
US03950343

反応ノート

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