Hydrochloric Acid → 3,5-Dinitro-4-phenylbenzoic acid

HRID 1605541ノート

反応式

HRID 1605541 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([N+:20]([O-:22])=[O:21])[C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]([O:9]C)=[O:8])([O-:3])=[O:2].Cl>COCCO.[OH-].[Na+].O>[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([N+:20]([O-:22])=[O:21])[C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]([OH:9])=[O:8])([O-:3])=[O:2]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 21546857Methyl 3,5-dinitro-4-phenylbenzoate

生成物 1

HCID 124087663,5-Dinitro-4-phenylbenzoic acid

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 80192-Methoxyethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a stirred suspension of methyl 3,5-dinitro-4-phenylbenzoate (145 g) in 2-methoxyethanol (1.5 l), 2 N sodium hydroxide (300 ml) is added dropwise during about 30 minutes. After additional stirring for about 15 minutes, the resulting solution is acidified by the dropwise addition of 4 N hydrochloric acid (250 ml), and the mixture is thereafter diluted with water (about 3 l). After cooling, the resulting precipitate is collected by filtration, washed with water and dried. After recrystallization from aqueous ethanol, 3,5-dinitro-4-phenylbenzoic acid is obtained with a melting point of 219°-221° C.

後処理

  1. additionis added dropwise during about 30 minutes
  2. temperatureAfter cooling
  3. filtrationthe resulting precipitate is collected by filtration
  4. washwashed with water
  5. customdried
  6. customAfter recrystallization from aqueous ethanol

出典と根拠

ORDレコード
ord-4c8168bf01524a988dc6f94f110ccbc7
出典データセット
uspto-grants-1976_04
特許番号
US03950380

反応ノート

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