3-Nitro-4-phenyl-5-sulfamylbenzoic acid → 3-Amino-4-phenyl-5-sulfamylbenzoic acid

HRID 1605575ノート

反応式

HRID 1605575 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:19](=[O:22])(=[O:21])[NH2:20])[C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]([OH:9])=[O:8])([O-])=O>C(O)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([S:19](=[O:22])(=[O:21])[NH2:20])[C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]([OH:9])=[O:8]

参加物

4

反応物 1

HCID 215468433-Nitro-4-phenyl-5-sulfamylbenzoic acid

生成物 1

HCID 215468413-Amino-4-phenyl-5-sulfamylbenzoic acid

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 23938Palladium溶媒

実験手順

To a solution of 3-nitro-4-phenyl-5-sulfamylbenzoic acid (8.5 g) in acetic acid (100 ml), palladium (10%) on carbon (1.5 g) is added, and the mixture is hydrogenated. After 2-2.5 hours the theoretical amount of hydrogen has been absorbed, and the hydrogen uptake has subsided. The catalyst is removed by filtration, and the filtrate is evaporated in vacuo. The residue is recrystallized from acetic acid to give 3-amino-4-phenyl-5-sulfamylbenzoic acid with a melting point of 232.5°-237° C.

後処理

  1. customAfter 2-2.5 hours the theoretical amount of hydrogen has been absorbed
  2. customThe catalyst is removed by filtration
  3. customthe filtrate is evaporated in vacuo
  4. customThe residue is recrystallized from acetic acid

出典と根拠

ORDレコード
ord-8cf6a0da7ddb42d4960d7d943f93761f
出典データセット
uspto-grants-1976_04
特許番号
US03950380

反応ノート

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