p-Toluenesulfonic acid → 3-Amino-1-(2-fluorobenzyl)-pyrazol-5-one
反応式
C([O:3][C:4](=O)[CH:5]=[C:6]([NH2:10])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1.[F:23][C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[CH2:26][NH:27][NH2:28]>C(O)C>[NH2:10][C:6]1[NH:28][N:27]([CH2:26][C:25]2[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=2[F:23])[C:4](=[O:3])[CH:5]=1参加物
5
実験手順
30.2 g of β-amino-β-ethoxyacrylic acid ethyl ester together with 2 g of p-toluenesulphonic acid were dissolved in 300 ml of ethanol and 27.1 g of o-fluorobenzylhydrazine were added under nitrogen. After stirring for 2 hours, the mixture was left to stand overnight and the compound identified above, which had separated out as a precipitate, was filtered off and recrystallised from ethanol. Melting point: 146°, 11 g (27%).
後処理
- waitthe mixture was left
- waitto stand overnight
- customhad separated out as a precipitate
- filtrationwas filtered off
- customrecrystallised from ethanol
出典と根拠
- ORDレコード
- ord-dc04bdb333de40a0b0bed98c1f8a5dd5
- 出典データセット
- uspto-grants-1976_04
- 特許番号
- US03950528
反応ノート
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