Tetrahydrofuran → 1-Diallylcarbamoyl-3-isopropylsulphinyl-1,2,4-triazole

HRID 1606065ノート

反応式

HRID 1606065 の反応式
[CH:1]([S:4]([C:6]1[N:10]=[CH:9][NH:8][N:7]=1)=[O:5])([CH3:3])[CH3:2].[CH2:11]([N:14]([CH2:18][CH:19]=[CH2:20])[C:15](Cl)=[O:16])[CH:12]=[CH2:13].O1CCCC1>C(N(CC)CC)C>[CH2:11]([N:14]([CH2:18][CH:19]=[CH2:20])[C:15]([N:8]1[CH:9]=[N:10][C:6]([S:4]([CH:1]([CH3:3])[CH3:2])=[O:5])=[N:7]1)=[O:16])[CH:12]=[CH2:13]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 3449313Diallylcarbamyl chlorideHCID 1784610013-Isopropylsulphinyl-1,2,4-triazole

生成物 1

HCID 203550491-Diallylcarbamoyl-3-isopropylsulphinyl-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A mixture of 6.4 g. 3-isopropylsulphinyl-1,2,4-triazole, 8.0 ml. diallylcarbamoyl chloride, 25 ml. dry tetrahydrofuran and 10 ml. dry triethylamine was refluxed under anhydrous conditions for 2 hours. The cooled reaction mixture was filtered and the filtrate was distilled under reduced pressure to give an oily residue which subsequently solidified. This solid residue was recrystallized from petroleum ether (b.p. 60° - 80°C.) to give 1-diallylcarbamoyl-3-isopropylsulphinyl-1,2,4-triazole, m.p. 32° - 34°C. Elemental analysis satisfactory. EXAMPLE 19

後処理

  1. additionA mixture of 6.4 g
  2. customThe cooled reaction mixture
  3. filtrationwas filtered
  4. distillationthe filtrate was distilled under reduced pressure
  5. customto give an oily residue which
  6. customThis solid residue was recrystallized from petroleum ether (b.p. 60° - 80°C.)

出典と根拠

ORDレコード
ord-6720ec3f750a4b28b9eaac6d58f28bbd
出典データセット
uspto-grants-1976_04
特許番号
US03952001

反応ノート

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