Hydroxylamine → HCID 21433660、化合物

反応式

[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]21[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2.C1C2C(=CC=CC=2)CCC21CCC(=O)CC2.[NH2:32][OH:33].[OH-].[Na+]>>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]21[CH2:14][CH2:13][C:12](=[N:32][OH:33])[CH2:11][CH2:10]2

参加物

反応物 4

HCID 787Hydroxylamine

HCID 14798Sodium Hydroxide

HCID 12251269HCID 12251269、化合物

HCID 12251437HCID 12251437、化合物

生成物 1

HCID 21433660HCID 21433660、化合物

実験手順

The first step of the process comprises reacting a spiro (cyclohexane-1,2'-indan)-4-one (II) or a 3',4'-dihydrospiro[cyclohexane-1,2'(1'H)-naphthalen]-4-one (II) with an acid addition salt of hydroxylamine and an alkali metal hydroxide such as sodium hydroxide at reflux temperature for from about 4 to about 8 hours to obtain the corresponding spiro(cyclohexane-1,2'-indan)-4-one oxime (III) or the corresponding 3',4'-dihydrospiro[cyclohexane-1,2'-(1'H)naphthalen]-4-one oxime (III), respectively.