Triethylamine → 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

HRID 1606705

反応式

HRID 1606705 の反応式
Cl.[CH3:2][O:3][NH2:4].C(N(CC)CC)C.[CH:12]1([N:22]=[C:23]=[S:24])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[CH3:2][O:3][NH:4][C:23]([NH:22][CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1)=[S:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

生成物 1

HCID 213934961-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To an ice-cold, stirred mixture of 0.02 mole of methoxyamine hydrochloride and methylene chloride is added 0.02 mole of triethylamine. The mixture is then allowed to warm to about 15° C. to 25° C. while a solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate in methylene chloride is added dropwise. The mixture is stirred overnight at room temperature and then filtered. The filtrate is washed with water, dried (sodium sulfate), and the solvent evaporated at reduced pressure to give the title compound.

後処理

  1. additionis added dropwise
  2. filtrationfiltered
  3. washThe filtrate is washed with water
  4. dry with materialdried (sodium sulfate)
  5. customthe solvent evaporated at reduced pressure

出典と根拠

ORDレコード
ord-6a07729a154d4098a9a71e74fc3b55bb
出典データセット
uspto-grants-1976_04
特許番号
US03953506

関連ノート

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