Sodium Hydroxide → 1-Aminotetralin, (S)-
反応式
C(N[C@@H](C(O)=O)CCC(O)=O)(=O)C1C=CC=CC=1.[C@@H:19]1([NH2:29])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1.[OH-].[Na+]>O>[C@@H:19]1([NH2:29])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1参加物
4
実験手順
A slurry of 130.3 grams (0.36 mole) of (S)-1,2,3,4-tetrahydro-1-naphthylamine N-benzoyl-(R)-glutamic acid salt in ice and water is made basic by the addition of a cold solution of 34.0 grams (0.847 mole) of sodium hydroxide in water. The liberated amine is extracted with ether. The ether solution is dried over a mixture of magnesium sulfate and sodium hydroxide pellets. The ether is evaporated, and the amine distilled to give the product boiling point 72°C. to 77°C. at 0.6 mm, [α]D25 + 54.9° (c 5.2, benzene).
後処理
- extractionThe liberated amine is extracted with ether
- dry with materialThe ether solution is dried over a mixture of magnesium sulfate and sodium hydroxide pellets
- customThe ether is evaporated
- distillationthe amine distilled
出典と根拠
- ORDレコード
- ord-fa55a27f7e304b81aee9decba741f09b
- 出典データセット
- uspto-grants-1976_04
- 特許番号
- US03953606
反応ノート
読み込み中…