HCID 131710167、化合物 → H-Glu(OtBu)-Ser(tBu)-OtBu

HRID 1606828ノート

反応式

HRID 1606828 の反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:16][O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]>[Pd]>[NH2:1][C@H:2]([C:12]([NH:14][C@H:15]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:16][O:17][C:18]([CH3:20])([CH3:19])[CH3:21])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10]

参加物

3

反応物 1

HCID 131710167HCID 131710167、化合物

生成物 1

HCID 10916435H-Glu(OtBu)-Ser(tBu)-OtBu収率 83.4%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

2.5 g. of palladium-on-carbon are added to the solution of 17.2 g. (32 mmoles) of Z-30-31-OtBu in 350 ml. of methanol, and gaseous hydrogen is bubbled into the mixture for 1 hour. The catalyst is removed by filtration, the filtrate is evaporated to dryness under reduced pressure, the solid residue is mixed with petroleum ether, and the mixture is filtered. 10.97 g. (83.4 %) of H-Glu(OtBu)-Ser(tBu)-OtBu are obtained. M.p.: 78°-82° C, Rf11 = 0.4.

後処理

  1. customof methanol, and gaseous hydrogen is bubbled into the mixture for 1 hour
  2. customThe catalyst is removed by filtration
  3. customthe filtrate is evaporated to dryness under reduced pressure
  4. additionthe solid residue is mixed with petroleum ether
  5. filtrationthe mixture is filtered

出典と根拠

ORDレコード
ord-055ca1749ad24418b3d46b93683aecd7
出典データセット
uspto-grants-1976_04
特許番号
US03953415

反応ノート

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