Hydrochloric Acid → 2-(beta-Hydroxyethyl)amino-4-(beta-hydroxyethyl)amino-6-(beta-hydroxyethyl)aminonitrobenzene
反応式
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9](Cl)[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17].[CH2:19]([CH2:21][NH2:22])[OH:20].Cl>>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([NH:22][CH2:21][CH2:19][OH:20])[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]参加物
4
実験手順
0.0072 mole (2 g) of 2-(β-hydroxyethyl)amino-6-(β-hydroxyethyl)amino-4-chloronitrobenzene, synthesized in stage 1 of example 2, was heated at 100°-110° C. with 6 ml of ethanolamine for 6 hours. The reaction medium was diluted with ice water then brought to neutrallity by addition of concentrated hydrochloric acid to precipitate out the desired product. After filtering and hot drying under vacuum in the presence of P2O5, it was recrystallized from 96° ethanol. It melted at 200° C.
後処理
- customto precipitate out the desired product
- filtrationAfter filtering
- dry with materialhot drying under vacuum in the presence of P2O5, it
- customwas recrystallized from 96° ethanol
出典と根拠
- ORDレコード
- ord-392a6a096fe54f3890b1fdcbfecea432
- 出典データセット
- uspto-grants-1989_09
- 特許番号
- US04863482
反応ノート
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