Thionyl Chloride → 2-Bromomethylbenzoyl chloride

HRID 1606897

反応式

HRID 1606897 の反応式
[Br:1][CH2:2][C:3]1[C:4]([C:9]([OH:11])=O)=[CH:5][CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:14])=O>C1C=CC=CC=1.CN(C=O)C>[Br:1][CH2:2][C:3]1[C:4]([C:9]([Cl:14])=[O:11])=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 3460032-(Bromomethyl)benzoic acid

生成物 1

HCID 122516322-Bromomethylbenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 241Benzene溶媒

実験手順

--A solution of α-bromotoluic acid (1.08 g) in dry benzene (10 ml) was stirred for 2 hours with thionyl chloride (0.73 ml) and dry DMF (five drops). The reaction mixture was evaporated to dryness, taken up in toluene and evaporated again. The crude product was crystallized from n-hexane (10 ml, charcoal) thereby obtaining pure α-bromotoluic acid chloride (0.95 g) as white flakes.

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. customevaporated again
  3. customThe crude product was crystallized from n-hexane (10 ml, charcoal)

出典と根拠

ORDレコード
ord-a9975bce2bb948979e1ab38e7d6a5308
出典データセット
uspto-grants-1989_09
特許番号
US04863914

関連ノート

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