3-Aminoquinuclidine → N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-bromo-2,4-dimethoxybenzamide Monohydrochloride

HRID 1606920ノート

反応式

HRID 1606920 の反応式
[NH2:1][CH:2]1[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[Br:10][C:11]1[C:12]([O:22][CH3:23])=[CH:13][C:14]([O:20][CH3:21])=[C:15]([CH:19]=1)[C:16]([Cl:18])=[O:17]>O1CCCC1>[ClH:18].[N:4]12[CH2:9][CH2:8][CH:7]([CH2:6][CH2:5]1)[CH:2]([NH:1][C:16](=[O:17])[C:15]1[CH:19]=[C:11]([Br:10])[C:12]([O:22][CH3:23])=[CH:13][C:14]=1[O:20][CH3:21])[CH2:3]2

参加物

4

反応物 2

HCID 1232383-AminoquinuclidineHCID 135050985-Bromo-2,4-dimethoxybenzoyl chloride

生成物 1

HCID 14097661N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-bromo-2,4-dimethoxybenzamide Monohydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 3-aminoquinuclidine (1.12 g, 0.0089 mole) in 20 ml tetrahydrofuran was added dropwise to a stirred solution of 5-bromo-2,4-dimethoxybenzoyl chloride (2.50 g, 0.0089 mole) in 100 ml tetrahydrofuran. The mixture was stirred at ambient temperature for 65 hr, and the solid was collected by filtration to yield 2.77 g. Recrystallization from methanol-isopropyl ether gave 1.45 g (40.2%), m.p. 240°-243° C.

後処理

  1. filtrationthe solid was collected by filtration
  2. customto yield 2.77 g
  3. customRecrystallization from methanol-isopropyl ether
  4. customgave 1.45 g (40.2%), m.p. 240°-243° C.

出典と根拠

ORDレコード
ord-b5adc83d84674b8a9545c5a4029338ae
出典データセット
uspto-grants-1989_09
特許番号
US04863919

反応ノート

読み込み中…