C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12]([O:14]C2C=CC([N+]([O-])=O)=CC=2)=O)C=CC=CC=1.[CH2:36]([NH:38][CH2:39][CH3:40])[CH3:37].C(N(CC)CC)C.CC1C(=O)C2N3[C@@](OC)([C@H](COC(N)=O)C=2C(=O)C=1OC)[C@H]1N[C@H]1C3>CO>[CH2:36]([N:38]([CH2:39][CH3:40])[C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:14])[CH3:37]2-diethylaminocarbonylthioethylamine (formate: 184 mg) was prepared by subjecting N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (500 mg) and diethylamine (316 μl) to the similar reactions to those described in References 2 and 4. The product was dissolved in anhydrous methanol (4 ml). To the solution were added triethylamine (174 μl) and mitomycin A (273 mg: 0.75 molar equivalent). The reaction solution was treated in a similar manner to that described in Example 1 to obtain Compound 4 (130 mg) in the form of grayish blue powders with a yield of 60%.
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