Nitric Acid → 4-[(2-Aminoethyl)amino]-4-oxobutan-2-yl nitrate

HRID 1607125ノート

反応式

HRID 1607125 の反応式
[OH:1][CH:2]([CH3:10])[CH2:3][C:4]([NH:6][CH2:7][CH2:8][NH2:9])=[O:5].[N+:11]([O-])([OH:13])=[O:12]>C(OCC)C>[O:1]([CH:2]([CH3:10])[CH2:3][C:4]([NH:6][CH2:7][CH2:8][NH2:9])=[O:5])[N+:11]([O-:13])=[O:12]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 13715405HCID 13715405、化合物

生成物 1

HCID 137153344-[(2-Aminoethyl)amino]-4-oxobutan-2-yl nitrate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

30 g. 2-(3-Hydroxybutanoylamino)-ethylamine are slowly introduced, with stirring at 5° to 10° C., into 100% nitric acid. After stirring for 2 hours at 0° to 5° C., the reaction solution is stirred into 1 liter of ice-cooled anhydrous diethyl ether, the supernatant ethereal layer is decanted off, the separated oil is covered with methylene chloride and the base is liberated with sodium carbonate. After suction filtration and evaporation in a vacuum at a maximum bath temperature of 20° C., there are obtained 33 g. (84% of theory) of base in the form of an oil.

後処理

  1. customthe supernatant ethereal layer is decanted off
  2. filtrationAfter suction filtration and evaporation in a vacuum at a maximum bath temperature of 20° C., there
  3. customare obtained 33 g

出典と根拠

ORDレコード
ord-164b2e6913224446aa13747c5396098b
出典データセット
uspto-grants-1989_09
特許番号
US04863949

反応ノート

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