Trifluoroacetic acid → HCID 11552535、化合物

HRID 16072ノート

反応式

HRID 16072 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9].C(O)(C(F)(F)F)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])(=[O:9])=[O:28]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

生成物 1

HCID 11552535HCID 11552535、化合物

実験手順

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

後処理

  1. customThe solvent was removed in vacuo, water
  2. additionwas added
  3. extractionthe mixture was extracted with dichloromethane (three times)
  4. dry with materialThe organic extracts were dried (MgSO4)
  5. customevaporated
  6. customtriturated with ether

出典と根拠

ORDレコード
ord-4d43f8afcb5d4b9f9222be483f1f66a8
出典データセット
uspto-grants-2010_06
特許番号
US07737135B2

反応ノート

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