2-(Dimethylamino)ethanol → 6-(2-Dimethylaminoethoxy)imidazo[1,2-b]pyridazine

HRID 1607306

反応式

HRID 1607306 の反応式
[Na].Cl[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1.[CH3:12][N:13]([CH3:17])[CH2:14][CH2:15][OH:16]>>[CH3:12][N:13]([CH3:17])[CH2:14][CH2:15][O:16][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1

参加物

4

反応物 3

HCID 79022-(Dimethylamino)ethanolHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 5360545Sodium

生成物 1

HCID 200766166-(2-Dimethylaminoethoxy)imidazo[1,2-b]pyridazine

反応条件

温度
130 °C

実験手順

Sodium metal (0.25 g) and 6-chloroimidazo[1,2-b]pyridazine are added to 25 ml of 2-dimethylaminoethanol and the mixture is heated in a sealed tube for 3 hours at 130° C. After cooling, the solvent is evaporated and the residue is treated with water and extracted with methylene chloride. The organic layer is separated, washed with saturated sodium chloride solution and dried over MgSO4. Evaporation of the solvent gives the title compound as a viscous oil which solidified on standing. The yield is 2.5 g.

後処理

  1. temperatureAfter cooling
  2. customthe solvent is evaporated
  3. additionthe residue is treated with water
  4. extractionextracted with methylene chloride
  5. customThe organic layer is separated
  6. washwashed with saturated sodium chloride solution
  7. dry with materialdried over MgSO4
  8. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-00ffed7e2ede4aa993b9ae90c719b3c0
出典データセット
uspto-grants-1989_09
特許番号
US04864022

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