Thionyl Chloride → 2-Methyl-2-(4-pyridinylthio)propanoyl chloride

HRID 1607532ノート

反応式

HRID 1607532 の反応式
[CH3:1][C:2]([S:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:6])[C:3](O)=[O:4].S(Cl)([Cl:16])=O>>[CH3:1][C:2]([S:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:6])[C:3]([Cl:16])=[O:4]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 135191122-Methyl-2-(4-pyridinylthio)propionic acid

生成物 1

HCID 145999382-Methyl-2-(4-pyridinylthio)propanoyl chloride

実験手順

9.7 g of the product from step (b) was refluxed for 2 1/2 hours in 225 ml thionyl chloride. The mixture was concentrated in vacuo. The residue was triturated and concentrated in vacuo two times with toluene to yield a white solid which showed the expected carbonyl shift in the IR, indicative of an acid chloride.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was triturated
  3. concentrationconcentrated in vacuo two times with toluene
  4. customto yield a white solid which

出典と根拠

ORDレコード
ord-5985fda140f3428596db54047ef9ad24
出典データセット
uspto-grants-1989_09
特許番号
US04866068

反応ノート

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