Tetrahydrofuran → Ethoxyprecocene

HRID 1607653ノート

反応式

HRID 1607653 の反応式
O1CCC[CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[O:20][C:19]([CH3:27])([CH3:26])[CH2:18][C:17]2=O>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH2:25][CH3:2])[O:20][C:19]([CH3:27])([CH3:26])[CH:18]=[CH:17]2

参加物

4

反応物 3

HCID 8028TetrahydrofuranHCID 1033734H-1-Benzopyran-4-one, 2,3-dihydro-6,7-dimethoxy-2,2-dimethyl-HCID 21226445Aluminium lithium hydride

生成物 1

HCID 127846Ethoxyprecocene収率 88%

実験手順

In 80 ml of anhydrous tetrahydrofurane 5.0 g (20 millimoles) of 6-methoxy-7-methoxy-2,2-dimethyl-4-chromanone are dissolved whereupon 1.5 g of lithium aluminum hydride are added in small portions under stirring and the reaction mixture is heated to boiling for an hour. The reaction mixture is worked up according to Example 31. The product is purified by column chromatography. Thus 4.1 g of the desired compound are obtained in the form of a colorless oil, yield 88%.

後処理

  1. additionare added in small portions
  2. temperaturethe reaction mixture is heated
  3. waitto boiling for an hour
  4. customThe product is purified by column chromatography

出典と根拠

ORDレコード
ord-9a53fcbe4a39471b82e18eec502761f5
出典データセット
uspto-grants-1989_09
特許番号
US04866089

反応ノート

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