Potassium Carbonate → 2-(Oxiran-2-yl)benzene-1-sulfonamide

HRID 1607789

反応式

HRID 1607789 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10])=[CH2:2].C(=O)([O-])[O-:14].[K+].[K+]>C(Cl)(Cl)Cl>[O:14]1[CH2:2][CH:1]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:10])=[O:11]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 113674032-Ethenylbenzenesulfonamide

生成物 1

HCID 138845232-(Oxiran-2-yl)benzene-1-sulfonamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution consisting of 2-ethenylbenzenesulfonamide (1.5 g, 8.1 mmol) m-chloroperbenzoic acid (1.4 g, 8.1 mmol) and potassium carbonate (1.1 g, 8.1 mmol) in 150 ml of chloroform was stirred for 4 days at room temperature. The reaction was filtered and the filtrate was washed with saturated sodium bicarbonate. The organic layer was separated, dried and concentrated. The resulting oil was flash chromatographed (methylene chloride) to yield the subject compound as a white solid. m.p. 136°-139° C.

後処理

  1. filtrationThe reaction was filtered
  2. washthe filtrate was washed with saturated sodium bicarbonate
  3. customThe organic layer was separated
  4. customdried
  5. concentrationconcentrated
  6. customchromatographed (methylene chloride)

出典と根拠

ORDレコード
ord-589e1cb3c2544f2c8cbc5de97132190a
出典データセット
uspto-grants-1989_09
特許番号
US04867783

関連ノート

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