Benzoyl Peroxide → 3-(Bromomethyl)-1,2,4,5-tetrafluorobenzene
反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH3:11].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH2:11][Br:12]参加物
5
反応条件
- 温度
- 25 °C
実験手順
A mixture of 2,3,5,6-tetrafluorotoluene (1.7 g), N-bromosuccinimide (1.9 g), dry carbon tetrachloride (10 ml) and benzoyl peroxide (0.01 g) was heated at the reflux temperature for 20 hours, cooled to the ambient temperature (ca. 25° C.) filtered and the filtrate diluted with diethyl ether. The ethereal solution was washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents to yield 2,3,5,6-tetrafluorobenzyl bromide as a mobile colourlessoil.
後処理
- temperaturewas heated at the reflux temperature for 20 hours
- filtrationfiltered
- additionthe filtrate diluted with diethyl ether
- washThe ethereal solution was washed with water
- dry with materialdried over anhydrous magnesium sulphate
- concentrationconcentrated by evaporation of the solvents
出典と根拠
- ORDレコード
- ord-1e894d1a67874e6783eab0da040c1559
- 出典データセット
- uspto-grants-1989_09
- 特許番号
- US04868209
反応ノート
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