Benzoyl Peroxide → 3-(Bromomethyl)-1,2,4,5-tetrafluorobenzene

HRID 1607928

反応式

HRID 1607928 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH3:11].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH2:11][Br:12]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 788962,3,5,6-Tetrafluorotoluene

生成物 1

HCID 1043773-(Bromomethyl)-1,2,4,5-tetrafluorobenzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
25 °C

実験手順

A mixture of 2,3,5,6-tetrafluorotoluene (1.7 g), N-bromosuccinimide (1.9 g), dry carbon tetrachloride (10 ml) and benzoyl peroxide (0.01 g) was heated at the reflux temperature for 20 hours, cooled to the ambient temperature (ca. 25° C.) filtered and the filtrate diluted with diethyl ether. The ethereal solution was washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents to yield 2,3,5,6-tetrafluorobenzyl bromide as a mobile colourlessoil.

後処理

  1. temperaturewas heated at the reflux temperature for 20 hours
  2. filtrationfiltered
  3. additionthe filtrate diluted with diethyl ether
  4. washThe ethereal solution was washed with water
  5. dry with materialdried over anhydrous magnesium sulphate
  6. concentrationconcentrated by evaporation of the solvents

出典と根拠

ORDレコード
ord-1e894d1a67874e6783eab0da040c1559
出典データセット
uspto-grants-1989_09
特許番号
US04868209

関連ノート

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