2-Nitro-2-phenyl-1,3-propanediol → 2-Phenyl-1,3-propanediol

HRID 1608044

反応式

HRID 1608044 の反応式
[N+]([C:4]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH2:7][OH:8])[CH2:5][OH:6])([O-])=O.[H][H]>[Pd].CO>[C:9]1([CH:4]([CH2:5][OH:6])[CH2:7][OH:8])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 2

HCID 2243932-Nitro-2-phenyl-1,3-propanediolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 2541782-Phenyl-1,3-propanediol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

12 g. (0.06 mole) of 2-nitro-2-phenyl-1, 3-propanediol, 400 mg. of 5% palladium on calcium carbonate and 150 ml. of methanol are placed in a Parr hydrogenator bottle and reduced with hydrogen overnight. The mixture is filtered through Celite, concentrated to an oil and recrystallized from 30 ml. of toluene. The yield is 7.4 g. (80%) of product, M.P. 52°-4° C.

後処理

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated to an oil
  3. customrecrystallized from 30 ml

出典と根拠

ORDレコード
ord-dd8b2b0d25b54515aa678d53f4143dc4
出典データセット
uspto-grants-1989_09
特許番号
US04868327

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