1-Phenylpiperazine → 4-(2-Sulfoethyl)-1-phenylpiperazine
反応式
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:14][CH2:15][S:16]([O-:19])(=[O:18])=[O:17].[Na+]>O>[S:16]([CH2:15][CH2:14][N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)([OH:19])(=[O:18])=[O:17]参加物
4
実験手順
A 3.25 g quantity (20 mmols) of 1-phenylpiperazine is dissolved in 10 ml of water, and a solution of 4.3 g (20 mmols) of sodium 2-bromoethanesulfonate in 10 ml of water is added dropwise thereto at room temperature with stirring. The mixture is subjected to reaction at room temperature for 1 hour and then at 70° C. overnight, and cooled. The crystals precipitated are collected by filtration and recrystallized from water-acetone.
後処理
- customThe mixture is subjected to reaction at room temperature for 1 hour
- temperatureat 70° C. overnight, and cooled
- customThe crystals precipitated
- filtrationare collected by filtration
- customrecrystallized from water-acetone
出典と根拠
- ORDレコード
- ord-5c5d523a8df2484cb52f2cd0eb151ee6
- 出典データセット
- uspto-grants-1989_09
- 特許番号
- US04870078
反応ノート
読み込み中…