Sodium Hydroxide → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

HRID 1608211ノート

反応式

HRID 1608211 の反応式
C([NH:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7]1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10683176N-({4-[(4-Fluorophenyl)methyl]morpholin-2-yl}methyl)acetamide

生成物 1

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine (3.0 g) in 10% hydrochloric acid (50 ml) is refluxed with stirring for 4 hours. The reaction mixture is adjusted to pH 11 with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound as an oil.

後処理

  1. extractionextracted with chloroform
  2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. customRemoval of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-5294a44b751645709e9b69ea735d3844
出典データセット
uspto-grants-1989_09
特許番号
US04870074

反応ノート

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