2-Acetylaminomethyl-4-[3-(4-chlorophenoxy)propyl]morpholine → 4-[3-(4-Chlorophenoxy)propyl]-2-morpholinemethanamine
反応式
C([NH:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:7]1)(=O)C>[OH-].[Na+]>[NH2:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=2)[CH2:7]1参加物
3
実験手順
A mixture of 2-acetylaminomethyl-4-[3-(4-chlorophenoxy)propyl]morpholine (3.3 g) and 10% aqueous sodium hydroxide solution (60 ml) is refluxed with stirring for 20 hours. The reaction mixture is extracted with chloroform, and the organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound as an oil.
後処理
- temperatureis refluxed
- extractionThe reaction mixture is extracted with chloroform