Hydrazine hydrate (1:1) → Ethyl 2-(aminomethyl)morpholine-4-carboxylate
反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][N:13]2C(=O)C3=CC=CC=C3C2=O)[CH2:7]1)=[O:5])[CH3:2].O.NN>C(O)C>[NH2:13][CH2:12][CH:8]1[O:9][CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7]1参加物
4
実験手順
A mixture of N-[(4-ethoxycarbonyl-2-morpholinyl)methyl]phthalimide (10.0 g), 85% hydrazine hydrate (2.9 g), and ethanol (10 ml) is refluxed with stirring for 10 minutes. The reaction mixture is filtered and the filtrate is extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound (5.8 g) as an oil.
後処理
- temperatureis refluxed
- filtrationThe reaction mixture is filtered
- extractionthe filtrate is extracted with chloroform
- washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
- dry with materialdried over magnesium sulfate
- customRemoval of the solvent under reduced pressure
出典と根拠
- ORDレコード
- ord-d5e7ea2101ec49bdb961c19b407af6f1
- 出典データセット
- uspto-grants-1989_09
- 特許番号
- US04870074
反応ノート
読み込み中…