Sodium Hydroxide → HCID 10037975、化合物

HRID 1608228ノート

反応式

HRID 1608228 の反応式
C([NH:4][CH2:5][CH:6]1[O:11][CH:10]([CH3:12])[CH2:9][N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[CH2:7]1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][CH2:5][CH:6]1[O:11][CH:10]([CH3:12])[CH2:9][N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[CH2:7]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 198486042-Acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine

生成物 1

HCID 10037975HCID 10037975、化合物収率 85.4%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2-acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine (3.0 g) in 10% hydrochloric acid (60 ml) is refluxed with stirring for 2 hours. The reaction mixture is basified with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium choride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give the title compound (2.2 g) as an oil.

後処理

  1. extractionextracted with chloroform
  2. washThe organic layer is washed successively with water and saturated aqueous sodium choride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-d831fa94c3bb4e4887f42133d93c4b5a
出典データセット
uspto-grants-1989_09
特許番号
US04870074

反応ノート

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