7-Benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]octane → 1-Tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]octane

HRID 1608680ノート

反応式

HRID 1608680 の反応式
C([N:8]1[CH2:15][C:14]2([CH2:16][NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH:10]([CH2:11][CH2:12][O:13]2)[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:21]([O:20][C:18]([NH:17][CH2:16][C:14]12[CH2:15][NH:8][CH2:9][CH:10]1[CH2:11][CH2:12][O:13]2)=[O:19])([CH3:24])([CH3:22])[CH3:23]

参加物

4

反応物 1

HCID 217047517-Benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]octane

生成物 1

HCID 217047491-Tert-butoxycarbonylaminomethyl-2-oxa-7-aza-bicyclo[3.3.0]octane

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

12.2 g (34.5 mmol) of 7-benzyl-1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]octane are hydrogenated in 200 ml of ethanol on 7 g of palladium-active charcoal (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled.

後処理

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationdistilled

出典と根拠

ORDレコード
ord-d0ec2d3a4dec45378d3eb5ea1322658a
出典データセット
uspto-grants-1995_03
特許番号
US05395944

反応ノート

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