ethyl 2-(N-phenyl-N-propylamino)acetate → HCID 15225127、化合物

HRID 1608785

反応式

HRID 1608785 の反応式
[C:1]1([N:7]([CH2:11][C:12]([O:14]CC)=[O:13])[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[OH-].[Na+]>[C:1]1([N:7]([CH2:11][C:12]([OH:14])=[O:13])[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 14060107ethyl 2-(N-phenyl-N-propylamino)acetate

生成物 1

HCID 15225127HCID 15225127、化合物収率 68%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of the product obtained in EXAMPLE 108 (5.0 g) in ethanol (30 ml), 3N aqueous sodium hydroxide (30 ml) was added and the mixture was stirred for 10 minutes under reflux. The aqueous solution was concentrated under reduced pressure and washed with ether, acidified to pH 3 with 2N hydrochloric acid and extracted four times with ethyl acetate. The combined organic layer was washed with saturated sodium chloride, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 2.96 g (68%) of the objective compound.

後処理

  1. temperatureunder reflux
  2. concentrationThe aqueous solution was concentrated under reduced pressure
  3. washwashed with ether
  4. extractionextracted four times with ethyl acetate
  5. washThe combined organic layer was washed with saturated sodium chloride
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was crystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-18dcf2fbcc354b17936cdd9df7f79616
出典データセット
uspto-grants-1995_03
特許番号
US05397781

関連ノート

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