Hydride → 8-Fluoroquinolin-4-amine
反応式
[N:1]([C:4]1[C:13]2[C:8](=[C:9]([F:14])[CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1)=[N+]=[N-].[BH4-].[Na+].[H-]>C(O)C>[NH2:1][C:4]1[C:13]2[C:8](=[C:9]([F:14])[CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1参加物
5
実験手順
To a solution at 15°-20° C. of 4-azido-8-fluoroquinoline in 12 mL of absolute ethanol was added a portion of 0.57 g (0.015 mol) of sodium borohydride. A powerful exotherm with vigorous evolution of gas was observed. The solution was cooled in ice and the remainder of the hydride was added in small portions within five minutes. The ice bath was then removed. After about two hours, the mixture was poured into about 200 mL of ice water. The precipitate was collected and air dried overnight. Yield 1.35 g. M.P. 184°-186° C.
後処理
- temperatureThe solution was cooled in ice
- customThe ice bath was then removed
- additionthe mixture was poured into about 200 mL of ice water
- customThe precipitate was collected
- customair dried overnight
出典と根拠
- ORDレコード
- ord-270b9ec410a841399158ea7ee3967c68
- 出典データセット
- uspto-grants-1995_03
- 特許番号
- US05399564
反応ノート
読み込み中…