Sodium → HCID 178444960、化合物

HRID 1609290

反応式

HRID 1609290 の反応式
[NH:1]1[C:5]([CH:6]([O:8][C:9]2[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=2)[O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20](=[O:34])[C:21]2[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:23][CH:22]=2)[CH3:7])=[N:4][N:3]=[N:2]1.[Na:38]>CCOCC.C(O)C>[Na:38].[NH:4]1[C:5]([CH:6]([O:8][C:9]2[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=2)[O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20](=[O:34])[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:25][CH:26]=2)[CH3:7])=[N:1][N:2]=[N:3]1

参加物

5

反応物 2

HCID 5360545SodiumHCID 178444959HCID 178444959、化合物

生成物 1

HCID 178444960HCID 178444960、化合物収率 92.5%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

In 30 ml of ether was dissolved 2.0 g of N-[2-[3-[1-(1H-tetrazol-5-yl)ethoxy]phenoxy]phenyl]-4-hexyloxybenzamide followed by addition of a solution of 90 mg of sodium in ethanol, and the mixture was concentrated in vacuo to dryness. After addition of isopropyl ether, the resulting foamy solid was pulverized, filtered and dried to give 1.9 g of the sodium salt as a white amorphous powder.

後処理

  1. concentrationthe mixture was concentrated in vacuo to dryness
  2. additionAfter addition of isopropyl ether
  3. filtrationfiltered
  4. customdried

出典と根拠

ORDレコード
ord-d1a9acbae6d7492d8361972f84ec0462
出典データセット
uspto-grants-1995_03
特許番号
US05399703

関連ノート

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