Sodium borohydride → 2-Cyclobutyl-4-thiazole methanol

HRID 1609331ノート

反応式

HRID 1609331 の反応式
[BH4-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([CH:13]2[CH2:16][CH2:15][CH2:14]2)[S:11][CH:12]=1)=O)C>C(O)C>[CH:13]1([C:10]2[S:11][CH:12]=[C:8]([CH2:6][OH:5])[N:9]=2)[CH2:14][CH2:15][CH2:16]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate

生成物 1

HCID 539708732-Cyclobutyl-4-thiazole methanol収率 101.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium borohydride (2.3 g) was added in portions over a 10 min period to an ice cold solution of 6.3 g of 2-cyclobutyl-4-thiazolecarboxylic acid ethyl ester in 100 ml of ethyl alcohol. The ice bath was removed and the reaction mixture stirred at room temperature for 30 hr during which an additional 0.46 g of sodium borohydride was added. The reaction mixture was then diluted with 200 ml of ice water and extracted with ethyl ether. The combined extracts were washed with water, dried (MgSO4) and condensed in vacuo to yield 5.1 g of 2-cyclobutyl-4-thiazole methanol as an oil.

後処理

  1. customThe ice bath was removed
  2. additionwas added
  3. additionThe reaction mixture was then diluted with 200 ml of ice water
  4. extractionextracted with ethyl ether
  5. washThe combined extracts were washed with water
  6. customdried
  7. custom(MgSO4) and condensed in vacuo

出典と根拠

ORDレコード
ord-b6e6e4147fd74d2584f307bd85b9e15a
出典データセット
uspto-grants-1995_03
特許番号
US05399702

反応ノート

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