Hydrochloric Acid → Isopropyl 1-methyl-3-indoleacetimidate hydrochloride

HRID 1609389

反応式

HRID 1609389 の反応式
[ClH:1].[CH3:2][N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12][C:13]#[N:14])=[CH:4]1.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[ClH:1].[CH3:2][N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12][C:13](=[NH:14])[O:18][CH:15]([CH3:17])[CH3:16])=[CH:4]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 106547202-(1-methyl-1H-indol-3-yl)acetonitrile

生成物 1

HCID 22907276Isopropyl 1-methyl-3-indoleacetimidate hydrochloride収率 44%

実験手順

Hydrogen chloride was bubbled through a stirred solution of 7.5 g (44 mmol) of 1-methylindole-3-acetonitrile in 100ml of dry isopropanol at room temperature. After 4 hours, the solvent was removed under reduced pressure and the residue was triturated with diethyl ether to give 5.17 g (44%) of isopropyl 1-methyl-3-indoleacetimidate hydrochloride as a white solid of melting point 133° C.

後処理

  1. customthe solvent was removed under reduced pressure
  2. customthe residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-968189737b3e40409f7af5ed50844dcc
出典データセット
uspto-grants-1995_03
特許番号
US05399712

関連ノート

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