3-Pyridinemethanamine → 2-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide

HRID 1609595

反応式

HRID 1609595 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][O:8][C:9]2=[O:12])=[CH:5][CH:4]=1.[NH2:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1>>[OH:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:11][C:10]=1[C:9]([NH:13][CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:12]

参加物

3

反応物 2

HCID 310183-PyridinemethanamineHCID 3305396-Methoxyphthalide

生成物 1

HCID 200820052-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide収率 91.8%

反応条件

温度
150 °C

実験手順

A mixture of 919 mg of 6-methoxyisobenzofuran-1 (3H)-one and 1.82 g of 3-aminomethylpyridine was heated at 150° C. without solvent for 3 hours under stirring. After finishing the reaction, the mixture was chromatographed on a column of silica gel, eluting with ethyl acetate and then with tetrahydrofuran to give 1.40 g of the titled compound.

後処理

  1. customthe reaction
  2. customthe mixture was chromatographed on a column of silica gel
  3. washeluting with ethyl acetate

出典と根拠

ORDレコード
ord-c962d1214f004a7bb3220bdf4e352a35
出典データセット
uspto-grants-1995_03
特許番号
US05401756

関連ノート

読み込み中…