Thionyl Chloride → 2-Chloromethyl-3-methoxy-5-phenyl-pyrazine

HRID 1609834ノート

反応式

HRID 1609834 の反応式
[CH3:1][O:2][C:3]1[C:4]([CH2:15]O)=[N:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:8]=1.O=S(Cl)[Cl:19]>C(Cl)Cl>[Cl:19][CH2:15][C:4]1[C:3]([O:2][CH3:1])=[N:8][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][N:5]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22260379HCID 22260379、化合物

生成物 1

HCID 222603922-Chloromethyl-3-methoxy-5-phenyl-pyrazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (3-methoxy-5-phenyl-pyrazin-2-yl)-methanol (60 mg, 0.28 mmol) in DCM (5 mL) is added SOCl2 (5 eq) at room temperature. The mixture is stirred at room temperature for an additional one hour. Solvent and volatile materials are removed in vacuo to dryness to give 65 mg of 2-chloromethyl-3-methoxy-5-phenyl-pyrazine as an oil.

後処理

  1. customSolvent and volatile materials are removed in vacuo to dryness

出典と根拠

ORDレコード
ord-73644287c2e846038606a8c2b82dbad1
出典データセット
uspto-grants-2006_01
特許番号
US06982268B2

反応ノート

読み込み中…