Triethylamine → ethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate

HRID 1610027

反応式

HRID 1610027 の反応式
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:4]=1[C:5]#[N:6].[CH2:13]([O:15][C:16](=[O:21])[C@H:17]([CH2:19][SH:20])N)[CH3:14].C(N(CC)CC)C>C(O)C>[CH2:13]([O:15][C:16]([C@@H:17]1[CH2:19][S:20][C:5]([C:4]2[CH:7]=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:3]=2[O:2][CH3:1])=[N:6]1)=[O:21])[CH3:14]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 13359Ethyl L-cysteinateHCID 777502,4-Dimethoxybenzonitrile

生成物 1

HCID 17747724ethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,4-Dimethoxybenzonitrile, (R)-cysteine ethyl ester and about 5 equivalents of triethylamine are refluxed in ethanol for about 6–8 hours to obtain ethyl-2-(2,4-dimethoxyphenyl)-4,5-dihydro-thiazole-4-(R)-carboxylate.

出典と根拠

ORDレコード
ord-495c069965fd4491b5366627893a9e8e
出典データセット
uspto-grants-2006_01
特許番号
US06982335B2

関連ノート

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