Ethyl 3-nitro-1-naphthoate → Ethyl 3-aminonaphthalene-1-carboxylate
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2参加物
4
実験手順
A solution of ethyl 3-nitro-1-naphthoate (5.371 g, 21.90 mmol) in ethanol (30 ml) was hydrogenated under normal temperature and normal pressure using 10% palladium/carbon (containing water by 50%) (0.5 g) as a catalyst until the starting material disappeared. The catalyst was filtered off and the solvent was evaporated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (hexane/ethyl acetate=6/1−3/1) to give the objective substance.
後処理
- filtrationThe catalyst was filtered off
- customthe solvent was evaporated under reduced pressure
- customThe obtained crude product
- customwas purified by silica gel column chromatography (hexane/ethyl acetate=6/1−3/1)
- customto give the objective substance
出典と根拠
- ORDレコード
- ord-cb67d76bd3f0405ea8b3b9ef0956d607
- 出典データセット
- uspto-grants-2006_01
- 特許番号
- US06982348B2
反応ノート
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