Sodium Hydroxide → 5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid

HRID 1610326ノート

反応式

HRID 1610326 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[C:4]([C:11]([O:13]CC)=[O:12])[CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:6][C:5]([C:7]([F:8])([F:9])[F:10])=[C:4]([C:11]([OH:13])=[O:12])[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2737208Ethyl 5-methyl-2-(trifluoromethyl)furan-3-carboxylate

生成物 1

HCID 27821835-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 5-methyl-2-(trifluoromethyl)-3-furancarboxylate (25 g, 113 mmol) in ethanol (200 ml) was added 2N aqueous sodium hydroxide solution (61.9 ml, 123.8 mmol) and the mixture was heated under reflux for 45 min. The reaction solution was concentrated, diluted with water (150 ml), and 6N hydrochloric acid was gradually added to adjust to about pH 5. The precipitated crystals were collected by filtration, washed with water to give 5-methyl-2-(trifluoromethyl)-3-furancarboxylic acid (20.5 g, 94%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 45 min
  3. concentrationThe reaction solution was concentrated
  4. additiondiluted with water (150 ml), and 6N hydrochloric acid
  5. additionwas gradually added
  6. filtrationThe precipitated crystals were collected by filtration
  7. washwashed with water

出典と根拠

ORDレコード
ord-fe4b792014ad49a490abfa9ccd3cabf8
出典データセット
uspto-grants-2006_01
特許番号
US06982348B2

反応ノート

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