関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl 4-(pyridin-3-yloxy)benzoate | HCID 22262109 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Pyridin-3-yloxy)benzoic acid | HCID 22261667 | — |
反応手順
To a solution of benzyl 4-(pyridin-3-yloxy)benzoate (18.0 g, 5.90 mmol) in ethanol (300 ml) was added 10% palladium/carbon (containing water by 50%, 2.0 g), and the mixture was stirred under a hydrogen stream at 80° C. overnight. The reaction solution was filtered with celite and the filtrate was concentrated. The residue was recrystallized from ethanol-hexane to give the objective substance (11.2 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06982348B2 |
|---|
| 出典データセット | uspto-grants-2006_01 |
|---|
| ORD ID | ord-1296fd1aaed04fa7848a8fa4f645c4b3 |
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| 出典メモ | uspto-grants-2006_01 |
|---|
