Sodium Hydroxide → 2-(1-Carboxypentoxy)benzoic acid

HRID 1611055ノート

反応式

HRID 1611055 の反応式
C[O:2][C:3]([CH:5]([O:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([O:15]C)=[O:14])[CH2:6][CH2:7][CH2:8][CH3:9])=[O:4].[OH-].[Na+]>CO.O>[C:3]([CH:5]([O:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([OH:15])=[O:14])[CH2:6][CH2:7][CH2:8][CH3:9])([OH:4])=[O:2]

参加物

5

反応物 2

HCID 14798Sodium Hydroxide2 回HCID 10446375Methyl 2-(1-methoxycarbonylpentoxy)benzoate

生成物 1

HCID 222597062-(1-Carboxypentoxy)benzoic acid収率 87%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

13.0 g of methyl 2-(1-methoxycarbonylpentoxy)benzoate were dissolved in methanol in a 250 ml flask, and a solution of 9.1 g of sodium hydroxide in 40 ml of water was added. The reaction mixture was stirred at 40° C. for one hour, during which a precipitate formed. This was dissolved after cooling to room temperature by adding further methanol and sodium hydroxide solution. The reaction mixture was washed with dichloromethane, and the aqueous phase was subsequently adjusted to pH 0 with concentrated hydrochloric acid while cooling in ice. A colourless solid precipitated during this and was filtered off and dried. 10.1 g (87% of theory) of 2-(1-carboxypentoxy)benzoic acid were obtained in this way.

後処理

  1. customformed
  2. dissolutionThis was dissolved
  3. temperatureafter cooling to room temperature
  4. washThe reaction mixture was washed with dichloromethane
  5. temperaturewhile cooling in ice
  6. customA colourless solid precipitated during this and
  7. filtrationwas filtered off
  8. customdried

出典と根拠

ORDレコード
ord-67d3bae6b7ed48b9b99bb068392992be
出典データセット
uspto-grants-2006_01
特許番号
US06984741B2

反応ノート

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