Thionyl Chloride → 61350-60-5
反応式
[N:1]1([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3](O)=[O:4].S(Cl)([Cl:21])=O>C(Cl)Cl>[N:1]1([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([Cl:21])=[O:4]参加物
4
実験手順
A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.
後処理
- temperatureis heated
- temperatureto reflux under nitrogen for 20 minutes
- concentrationconcentrated in vacuo
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7b1509fd6ce941f1be3c1f12adce7045
- 出典データセット
- uspto-grants-2006_01
- 特許番号
- US06987104B2
反応ノート
読み込み中…